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The effect of 4-amino-5-imidazolecarboxamide on the synergistic antineoplastic activity of 6-chloropurine and azaserine

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Zusammenfassung

4-Amino-5-imidazolcarboxamid hat eine antagonistische Wirkung auf die synergistische Tumorhemmung, die sich aus der gemeinsamen Anwendung von 6-Chlorpurin und Azaserin ergibt. Dies steht im Einklang mit der Fähigkeit des 4-Amino-5-imidazolcarboxamids, auch die Hemmung des Einbaues von C14-Format in das Guanin von Polynucleotiden, durch 6-Chlorpurin hervorgerufen, teilweise zu unterbinden.

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Authors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA

    A. C. Sartorelli & Barbara A. Booth

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  1. A. C. Sartorelli
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  2. Barbara A. Booth
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Sartorelli, A.C., Booth, B.A. The effect of 4-amino-5-imidazolecarboxamide on the synergistic antineoplastic activity of 6-chloropurine and azaserine. Experientia 21, 457–458 (1965). https://doi.org/10.1007/BF02150818

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