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Metabolism of pyridoxal phosphate in the liver of hypo- and hyperthyroid rats

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  • Chimica. Biochimica
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Riassunto

È stata determinata nel fegato di ratti normali, ipotiroidei ed ipertiroidei l'attività degli enzimi che portano alla sintesi del piridossalfosfato, la piridossalcinasi e la piridossaminfosfatoossidasi, e del primo enzima che ne catalizza la demolizione, una fosfatasi. In condizioni di ipertiroidismo sono aumentate la piridossalcinasi e la fosfatasi, mentre la ossidasi è invariata; nell'ipotiroidismo invece non si osservano modificazioni significative. La quantità di acido piridossico escreta con l'urina è diminuita nell'ipotiroidismo e aumentata nell'ipertiroidismo.

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Authors and Affiliations

  1. Institute of Biochemistry, University of Torino, Italy

    M. A. Grillo & G. P. Pescarmona

Authors
  1. M. A. Grillo
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  2. G. P. Pescarmona
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Additional information

This investigation was supported by Research Grant No. AM-05676 from the United States Public Health Service.

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Grillo, M.A., Pescarmona, G.P. Metabolism of pyridoxal phosphate in the liver of hypo- and hyperthyroid rats. Experientia 23, 719–720 (1967). https://doi.org/10.1007/BF02154133

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  • DOI: https://doi.org/10.1007/BF02154133

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