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Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys

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  • Chimica, Biochimica, Biophysica
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Riassunto

Scimmie scoiattolo trattate cronicamente con MnO2 presentano disturbi del sistema extrapiramidale ed una riduzione delle concentrazioni di serotonina e dopamina nel nucleo caudato. L'intensità dei disturbi extrapiramidali e la riduzione della concentrazione delle amine nel caudato appaiono correlate.

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Author notes

  1. N. H. Neff & E. Costa

    Present address: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, William A. White Building, Saint Elizabeths Hospital, 20032, Washington, D.C.

Authors and Affiliations

  1. Departments of Pharmacology and Neurology, College of Physicians and Surgeons of Columbia University, 10032, New York, N.Y., USA

    N. H. Neff, R. E. Barrett & E. Costa

Authors
  1. N. H. Neff
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  2. R. E. Barrett
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  3. E. Costa
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Additional information

This work was supported in part by the Clinical Research Center for Parkinson's and Allied Diseases, NB 05184, and the Parkinson Information Center, a part of the National Information Network of NINDB under contract NIH-69-76.

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Neff, N.H., Barrett, R.E. & Costa, E. Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys. Experientia 25, 1140–1141 (1969). https://doi.org/10.1007/BF01900234

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  • DOI: https://doi.org/10.1007/BF01900234

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