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Enhancement of tyrosine transamination in vivo by catecholamines

  • Specialia
  • Pharmalogica
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Zusammenfassung

Bei normalen Ratten bewirkenl-Dihydroxyphenylalanin, Dopamin, Noradrenalin und Adrenalin eine Herabsetzung des Plasma-Tyrosins, eine erhöhte Ausscheidung vonp-Phenylbrenztraubensäure im Urin und eine Zunahme der Aktivität der Tyrosin-Aminotransferase der Leber. Es wird daraus geschlossen, dass Catecholamine die extrazerebrale Transaminierung von Tyrosin steigern und dass die Tyrosin-Transaminierung möglicherweise an der Regulation der Catecholamin-Biosynthese beteiligt ist.

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Authors and Affiliations

  1. Research Department, F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basle, Switzerland

    G. Bartholini, K. F. Gey & A. Pletscher

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  1. G. Bartholini
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  2. K. F. Gey
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  3. A. Pletscher
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Bartholini, G., Gey, K.F. & Pletscher, A. Enhancement of tyrosine transamination in vivo by catecholamines. Experientia 26, 980–981 (1970). https://doi.org/10.1007/BF02114143

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  • DOI: https://doi.org/10.1007/BF02114143

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