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Human placental alkaline phosphatase, an inhibitor of hemagglutination by PR8-influenza A virus

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Résumé

La phosphatase alkaline du placenta humain est un sialyglycoenzyme qui inhibe l'hémagglutination (HA) produite par leVirus influenzae A (PR-8). L'enzyme de poids moléculaire élevé donne un titre HA-I beaucoup plus grand que les enzymes de poids moléculaire inférieur L'élimination de l'acide sialique de l'enzyme par traitement à la neuraminidase ou par oxydation des carbohydrates avec du périodate ou par protéolyse amènent une réduction prononcée du titre de HA-I.

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Authors and Affiliations

  1. Departments of Medicine, Pharmacology and the Stella and Charles Guttman Laboratory for Human Pharmacology and Pharmacogenetics, New York University Medical Center, 550 First Avenue, 10016, New York, N.Y., USA

    N. K. Ghosh, A. Rukenstein, C. Labowsky & R. P. Cox

Authors
  1. N. K. Ghosh
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  2. A. Rukenstein
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  3. C. Labowsky
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  4. R. P. Cox
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Additional information

Supported by NIH Research Grant No. GM11508 and Career Scientist Award to R.P.C. by the Health Research Council of the City of New York. N.K.G. is grateful to Dr. P. Calabresi for his help and support.

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Ghosh, N.K., Rukenstein, A., Labowsky, C. et al. Human placental alkaline phosphatase, an inhibitor of hemagglutination by PR8-influenza A virus. Experientia 30, 333–335 (1974). https://doi.org/10.1007/BF01921647

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