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A new pyroglutamylpeptide (Pyr-Lys-Ser) isolated from the venom ofAgkistrodon halys blomhoffii

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Zusammenfassung

Es wird über die Strukturklärung eines neuen pyroglutaminsäurehaltigen Peptids aus dem Gift vonAgkistrodon halys blomhoffii berichtet.

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Literatur

  1. H. Kato andT. Suzuki, Experientia25, 694 (1969); Biochemistry10, 972 (1971).

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  2. K. Okada, T. Uyehara, M. Hiramoto, H. Kato andT. Suzuki, Chem. Pharm. Bull.21, 2217 (1973).

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  3. H. Kato, T. Suzuki, K. Okada, T. Kimura andS. Sakakibara, Experientia29, 574 (1973).

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  5. The spectrum (Figure) showed prominent peaks atm/e 453, 481 and 512. The sequence of Pyr-Lys-Thr, in which the C-terminal serine of (I) is replaced by threonine, seemed to account for these peaks; the acid hydrolysate of (I) gave about 0.07 residue of threonine. These observations may suggest that the preparation of (I) was contaminated by an analogous peptide Pyr-Lys-Thr which was not separated from (I) on paper electrophoresis and paper chromatography.

  6. The abbreviations used are: Pyr, pyroglutamyl; BOC,tert.-butyloxycarbonyl; Z, benzyloxycarbonyl; OSu, N-hydroxysuccinimide ester; OTCP, 2, 4, 5-trichlorophenyl ester. Satisfactory elementary analyses and chromatographic data were obtained for all the compounds described.

  7. H. Kato, S. Iwanaga andT. Suzuki, Experientia22, 49 (1966).

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  8. Acknowledgment. We wish to thank ProfessorT. Suzuki of Osaka University for his interest and encouragement and also MissT. Tsuji of Kanazawa University for her assistance in mass spectrometric analyses.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa, Japan

    K. Okada, S. Nagai & H. Kato

  2. Institute for Protein Research, Osaka University, Yamada Kami, Suita, Osaka, Japan

    K. Okada, S. Nagai & H. Kato

Authors
  1. K. Okada
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  2. S. Nagai
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  3. H. Kato
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Okada, K., Nagai, S. & Kato, H. A new pyroglutamylpeptide (Pyr-Lys-Ser) isolated from the venom ofAgkistrodon halys blomhoffii. Experientia 30, 459–460 (1974). https://doi.org/10.1007/BF01926291

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  • DOI: https://doi.org/10.1007/BF01926291

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