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2-Allyl-2-isopropylacetylurea and its influence on the haematopoetic system

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Zusammenfassung

Wenn Ratten längere Zeit mit 2-Allyl-2-isopropylacetylharnstoff behandelt werden, finden sich in verschiedenen Organen grün-braune Pigmente. Diese vorwiegend in Microsomen lokalisierten Produkte stammen vom Häm des Cytochroms P-450 sowie anderen Hämoproteinen. Am hämatopoetischen System konnten demgegenüber keine Veränderungen gefunden werden. Damit ist der Schluss gestattet, dass der für die Hämdenaturierung verantwortliche aktive Metabolit eine sehr kurze Halbwertzeit haben muss.

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Authors and Affiliations

  1. Biological and Medical Research Division, Sandoz Ltd., CH-4002, Basel, Switzerland

    G. Rentsch & A. Johnston

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  1. G. Rentsch
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  2. A. Johnston
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Rentsch, G., Johnston, A. 2-Allyl-2-isopropylacetylurea and its influence on the haematopoetic system. Experientia 31, 208–209 (1975). https://doi.org/10.1007/BF01990709

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  • DOI: https://doi.org/10.1007/BF01990709

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