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Cytotoxicity of new cytochalasans fromChaetomium globosum

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Zusammenfassung

Nachweis, dass CHCl3-Rohextrakte aus Myzelien und Filtraten der Zuchtmedien vonChaetomium globosum Kunze ex Fries einen akuten toxischen Effect auf HeLa-Zellen in vitro, sowie auf Mäuse zeigten. Chaetoglobosine die aus Mycelium-Rohextrakt isoliert wurden und chemisch zu den Cytochalasanen gehören, induzierten in HeLa-Zellen eine Polynukleierung und multipolare Kernverteilung. Auch beim Chaetogobosin wird eine Mikrofilament-Schädigung angenommen.

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References

  1. M. Saito, K. Ohtsubo, M. Umeda, M. Enomoto, H. Kurata, S. Udagawa, F. Sakabe andM. Ichinoe, Japan. J. exp. Med.41, 1 (1971).

    Google Scholar 

  2. M. Saito, T. Ishiko, M. Enomoto, K. Ohtsubo, M. Umeda, H. Kurata, S. Udagawa, S. Taniguchi andS. Sekita, Japan. J. exp. Med.44, 53 (1974).

    Google Scholar 

  3. M. Umeda, T. Yamashita, M. Saito, S. Sekita, C. Takahashi, K. Yoshihira, S. Natori, H. Kurata andS. Udagawa, Japan. J. exp. Med.44, 73 (1974).

    Google Scholar 

  4. S. Sekita, K. Yoshihira, S. Natori andH. Kuwano, Tetrahedron Lett.1973, 2109.

  5. M. Binder andC. Tamm, Angew. Chem., int. edn.12, 370 (1973).

    Google Scholar 

  6. S. B. Carter, Endevour113, 77 (1972).

    Google Scholar 

  7. G. Buchi, Y. Kitaura, S.-S. Yuan, H. E. Wright, J. Clardy, A. L. Demain, T. Glinsukon, N. Huntand, G. N. Wogan, J. Amer. chem. Soc.95, 5423 (1973).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, (Japan)

    M. Umeda, K. Ohtsubo & M. Saito

  2. Department of Phytochemistry, National Institute of Hygienic Sciences, Setagaya-ku, Tokyo, (Japan)

    S. Sekita, K. Yoshihira & S. Natori

  3. Department of Microbiology, National Institute of Hygienic Sciences, Setagaya-ku, Tokyo, (Japan)

    S. Udagawa, F. Sakabe & H. Kurata

Authors
  1. M. Umeda
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  2. K. Ohtsubo
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  3. M. Saito
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  4. S. Sekita
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  5. K. Yoshihira
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  6. S. Natori
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  7. S. Udagawa
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  8. F. Sakabe
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  9. H. Kurata
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Umeda, M., Ohtsubo, K., Saito, M. et al. Cytotoxicity of new cytochalasans fromChaetomium globosum . Experientia 31, 435–438 (1975). https://doi.org/10.1007/BF02026363

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  • DOI: https://doi.org/10.1007/BF02026363

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