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Penetration of C14-labelled rifampicin into primate peripheral nerve

  • Pharmacologica
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Summary

The penetration of C14 Rifampicin into various tissues, but particularly peripheral nerve, has been studied in the monkey. Penetration into the substance of peripheral nerve internal to the epineurial covering was demonstrated and the significance of this in relation to the treatment of leprosy is discussed.

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Authors and Affiliations

  1. Department of Human Anatomy, the University, OX1 3QX, Oxford, (England)

    A. C. McDougall, J. A. Rose & D. G. Grahame-Smith

  2. Medical Research Council Clinical Pharmacology Unit, the Radcliffe Infirmary, OX1 3QX, Oxford, (England)

    A. C. McDougall, J. A. Rose & D. G. Grahame-Smith

Authors
  1. A. C. McDougall
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  2. J. A. Rose
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  3. D. G. Grahame-Smith
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Additional information

Acknowledgement. This work was supported by grants toColin McDougall from the Medical Research Council and the British Leprosy Relief Association (LEPRA). We wish to record our thanks to Ciba-Geigy in the United Kingdom and Switzerland for supplying the labelled drug, and to DrsK. Brown-Grant andG. J. R. Hovell for invaluable help in carrying out this experiment.

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McDougall, A.C., Rose, J.A. & Grahame-Smith, D.G. Penetration of C14-labelled rifampicin into primate peripheral nerve. Experientia 31, 1068–1069 (1975). https://doi.org/10.1007/BF02326964

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  • DOI: https://doi.org/10.1007/BF02326964

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