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Struktur-Wirkungsbeziehungen beim menschlichen Calcitonin. III. Die biologische Aktivität verkürzter oder an den Kettenenden modifizierter, synthetischer analoger

Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or termnally modified peptide chains

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Summary

Assays of 8 synthetic analogues of human calcitonin in rats showed that their hypocalcaemic activity was drastically reduced by deletion of the C-terminal amide group, chain-shortening or opening of the disulphide ring, but unaffected or enhanced by modification of the N-terminal amino group.

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References

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Authors and Affiliations

  1. Forschungslaboratorien der Division Pharma der Ciba-Geigy AG., CH-4002, Basel, Schweiz

    W. Rittel, R. Maier, M. Brugger, B. Kamber, B. Riniker & P. Sieber

Authors
  1. W. Rittel
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  2. R. Maier
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  3. M. Brugger
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  4. B. Kamber
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  5. B. Riniker
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  6. P. Sieber
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Additional information

II. vgl.R. Maier, B. Kamber, B. Riniker andW. Rittel, Hormon. Metab. Res.7, 511 (1975).

Die hier verwendete, abgekürzte Schreibweise für Peptide folgt den Empfehlungen der IUPAC-IUB Kommission für Biochemische Nomenklatur, J.B.C.247, 977 (1972). Weitere Abkürzungen: HCT, Human-Calcitonin; PCT, Schweinecalcitonin; Bmp, β-Mercaptopropionsäure (Desaminocystein); NMet, Normethionin (S-Methylcystein); -OMe, Methylester.

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Rittel, W., Maier, R., Brugger, M. et al. Struktur-Wirkungsbeziehungen beim menschlichen Calcitonin. III. Die biologische Aktivität verkürzter oder an den Kettenenden modifizierter, synthetischer analoger. Experientia 32, 246–248 (1976). https://doi.org/10.1007/BF01937791

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  • DOI: https://doi.org/10.1007/BF01937791

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