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Pentobarbital: Presynaptic effect in the squid giant synapse

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Summary

In concentrations that produced synaptic blockade in the squid giant synapse, sodium pentobarbital produced a dose-related, reversible decrease of the ‘calcium spike’ of the presynaptic terminal.

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Author information

Author notes

  1. K. G. Morgan

    Present address: Department of Physiology and Biophysics, Mayo Medical School, 55901, Rochester, Minnesota, USA

Authors and Affiliations

  1. Dept. of Pharmacology, College of Medicine, University of Cincinnati, 45267, Cincinnati, Ohio, USA

    K. G. Morgan & S. H. Bryant

Authors
  1. K. G. Morgan
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  2. S. H. Bryant
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Additional information

This work was performed while Dr Morgan was a Grass Foundation Fellow at the Marine Biological Laboratory, Woods Hole, Massachusetts, USA.

The authors thank Dr J. Z. Yeh for the loan of the 4-aminopyridine and Dr G. H. Acheson for helpful suggestions.

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Morgan, K.G., Bryant, S.H. Pentobarbital: Presynaptic effect in the squid giant synapse. Experientia 33, 487–488 (1977). https://doi.org/10.1007/BF01922226

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  • DOI: https://doi.org/10.1007/BF01922226

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