Summary
High-affinity, Na+-independent binding of β-alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other α-amino acids, but not by taurine or GABA. This binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both β-alanine and glycine.
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This study was supported in part by Centro ‘Ramón y Cajal’ and Fundacion Juan March.
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DeFeudis, F.V., Muñoz, L.M.O., Vidal, M.A. et al. High-affinity binding ofβ-alanine to cerebral synaptosomes might involve glycine-receptors. Experientia 34, 1169–1170 (1978). https://doi.org/10.1007/BF01922937
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DOI: https://doi.org/10.1007/BF01922937