Summary
Short term organ cultures of lung fragments from neonatal mice maintain their normal architecture. Cultures exposed to silica flour in varying concentrations show effects resembling those seen in chronic silicosis produced by inoculation and inhalation methods.
Article PDF
Similar content being viewed by others
References
B. Goldstein and L. Webster, Br. J. ind. Med.23, 71 (1966).
E.J. King, G.P. Mohanty, C.V. Harrison and G. Nagelschmidt, Br. J. ind. Med.10, 76 (1953).
J. Marks and G. Nagelschmidt, Archs ind. Health20, 383 (1959).
J.M. Chen, Exp. Cell Res.7, 518 (1954).
J.F. Morgan, H.J. Morton and R.C. Parker, Proc. Soc. exp. Biol. Med.73, 1 (1950).
A.G. Heppleston Br. Med. Bull.25, 282 (1969).
A.G. Heppleston, N.A. Wright and J.A. Stewart, J. Path.101, 293 (1970).
A.C. Allison, J.S. Harington and M. Birbeck, J. exp. Med.124, 141 (1961).
J.S. Harington, S. Afr. med. J.37, 451 (1963).
J.M.G. Davis, Br. J. exp. Path.48, 371 (1967).
K.J. Rajan, J.C. Wagner and P.H. Evans, Nature238, 346 (1972).
J.M.G. Davis, Br. J. exp. Path.48, 379 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoshihara, H., Yew, D. Response of neonatal mouse lung in organ culture to silica. Experientia 34, 1187 (1978). https://doi.org/10.1007/BF01922949
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01922949