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Evidence for an involvement of acetylcholine in self-stimulation of the prefrontal cortex in the rat

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Summary

The effects of injections of antagonists of muscarinic and nicotinic receptors on self-stimulation of the prefrontal cortex in the rat were studied. The results of this investigation suggest that acetylcholine is involved in self-stimulation of the prefrontal cortex through activation of muscarinic receptors, and also suggest a possible interaction between acetylcholine and dopamine in mediating self-stimulation of this area of the brain.

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References

  1. F. Mora and R.D. Myers, Science197, 1387 (1977).

    Article  CAS  PubMed  Google Scholar 

  2. F. Mora, K.F. Sweeney, E.T. Rolls and A.M. Sanguinetti, Brain Res.116, 516 (1976).

    Article  CAS  PubMed  Google Scholar 

  3. F. Mora, Life Sci.22, 919 (1978).

    Article  CAS  PubMed  Google Scholar 

  4. A. Phillips and H. Fibiger, Can. J. Psychol.32, 58 (1978).

    Article  CAS  PubMed  Google Scholar 

  5. R.D. Myers and F. Mora, Brain Res. Bull.2, 105 (1977).

    Article  CAS  PubMed  Google Scholar 

  6. P.C. Emson, in: Advances in Biochemical Psychopharmacology, vol. 19, p. 397. Ed. P.J. Roberts, 1978.

  7. A.M. Sanguinetti, Thesis, University of Granada 1970.

  8. F. Mora, F. Alba, A.M. Sanguinetti, J.M. Rodriguez and F. Vives, Brain Res. Bull.5, 223 (1980).

    Article  CAS  PubMed  Google Scholar 

  9. S.N. Pradhan and K.A. Kamat, Archs int Pharmacodyn. Ther.196, 321 (1972).

    CAS  Google Scholar 

  10. L.M. Newman, J. comp. physiol. Psychol.79, 394 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. S.H. Snyder, S.P. Banarjee, H.I. Yamamura and C. Greenberg, Science184, 1243 (1974).

    Article  CAS  PubMed  Google Scholar 

  12. T. Hökfelt, A. Ljungdahl, K. Fuxe and O. Johansson, Science184, 177 (1974).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, University of Granada, Granada, Spain

    F. Mora, F. Vives & F. Alba

Authors
  1. F. Mora
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  2. F. Vives
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  3. F. Alba
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Additional information

Acknowledgment. We thank Professor C. Osorio for the support vigen to this research, and also Dr A. Martin and Miss Rosa Montes. We would also like to acknowledge Dr C.V. Gisolfi for his helpful comments on the manuscript. We thank Dr A. Wauquier and Janssen Pharmaceutica (Beerse, Beelgium) for their generous supply of dexetimide.

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Mora, F., Vives, F. & Alba, F. Evidence for an involvement of acetylcholine in self-stimulation of the prefrontal cortex in the rat. Experientia 36, 1180–1181 (1980). https://doi.org/10.1007/BF01976114

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  • DOI: https://doi.org/10.1007/BF01976114

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