Skip to main content
SpringerLink
Log in

Synthesis of 6-deoxy-6-fluoro-L-ascorbic acid

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

6-Deoxy-6-fluoro-L-ascorbic acid has been synthesized in 5 steps starting from 2,3-4,6-di-O-isopropylidene-2-keto-L-gulonic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. Heidelberger, N.K. Chaudhuri, P. Danneberg, D. Mooren, L. Griesbach, R. Duschinsky, R.J. Schnitzer, E. Pleven and J. Scheiner, Nature, Lond.179, 663 (1957).

    Article  CAS  PubMed  Google Scholar 

  2. J. Kollonitsch, S. Marburg and L.M. Perkins, J. org. Chem.44, 771 (1979).

    Article  CAS  Google Scholar 

  3. A.B. Foster and J.H. Westwood, Rev. pure appl. Chem.35, 147 (1973).

    Article  CAS  Google Scholar 

  4. L.S. Goodman and A. Gilman, in: The Pharmacological Basis of Therapeutics, 5th edn, p. 1491. Macmillan, New York 1975.

    Google Scholar 

  5. L. Evelyn and L.D. Hall, Carbohyd. Res.47, 285 (1976).

    Article  CAS  Google Scholar 

  6. T. Reichstein and A. Grüssner, Helv. chim. Acta17, 311 (1934).

    Article  CAS  Google Scholar 

  7. J. Kiss and H. Spiegelberg, Helv. chim. Acta47, 398 (1964).

    Article  CAS  Google Scholar 

  8. The corresponding chloro-, bromo-, and iodo-derivatives of L-ascorbic acid have also been synthesized. See: Swiss patent No. 5741, 5. Mai 1975.

  9. L.F. Johnson and W.C. Jankowski, Carbon-13 NMR Spectra. Wiley-Interscience, New York 1972.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmaceutical Research Department and Central Research Units, F. Hoffmann-La Roche & Co. Ltd, CH-4002, Basel, Switzerland

    J. Kiss & W. Arnold

Authors
  1. J. Kiss
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to Professor Albert Szent-Györgyi, National Foundation for Cancer Research, Marine Biological Laboratory, Woods Hole, Massachusetts, on the occasion of his 85th birthday.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kiss, J., Arnold, W. Synthesis of 6-deoxy-6-fluoro-L-ascorbic acid. Experientia 36, 1138–1139 (1980). https://doi.org/10.1007/BF01976086

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01976086

Search

Navigation