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Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma

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Summary

Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.

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References

  1. J.A. Greager and M.W. Baldwin, Cancer Res.38, 69 (1978).

    CAS  PubMed  Google Scholar 

  2. B.N. Halpern, F. Haguenau and K.H. Hollmann, in: Rôle du système réticulo-endothélial dans l'immunité antibactérienne et antitumorale, p. 249. Editions CNRS, Paris 1963.

    Google Scholar 

  3. M.G. Hanna, Jr, B. Zbar and H.J. Rapp, J. natl Cancer Inst.48, 1441 (1972).

    PubMed  Google Scholar 

  4. J.W. Kreider, G.L. Bartlett, D.M. Purnell and S. Webb, Cancer Res.38, 689 (1978).

    CAS  PubMed  Google Scholar 

  5. V.V. Likhite, Int. J. Cancer14, 684 (1974).

    Article  CAS  PubMed  Google Scholar 

  6. D.M. Purnell, J.R. Otterstrom, G.L. Bartlett and J.W. Kreider, J. natl Cancer Inst.56, 1171 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. M.T. Scott, J. natl. Cancer Inst.53, 855 (1974).

    Article  CAS  PubMed  Google Scholar 

  8. M.T. Scott, J. natl Cancer Inst.53, 861 (1974).

    Article  CAS  PubMed  Google Scholar 

  9. M.J. Snodgrass and M.G. Hanna Jr, Cancer Res.33, 701 (1973).

    CAS  PubMed  Google Scholar 

  10. M.F.A. Woodruff and N. Dunbar, Br. J. Cancer.32, 34 (1975).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. S.A. Rosenberg and H.J. Rapp, Med. Clin. North Am.60, 419 (1976).

    Article  CAS  PubMed  Google Scholar 

  12. B. Fisher, M. Gebhardt, J. Linta and E. Saffer, Cancer Res.38, 2679 (1978).

    CAS  PubMed  Google Scholar 

  13. V.V. Likhite, J. natl Cancer Inst.56, 985 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. B. Bizzini, B. Maro and P. Lallouette, Méd. Malad. infect.8, 408 (1978).

    Article  Google Scholar 

  15. C. Huggins, L.C. Grand and F.P. Brillantes, Nature189, 204 (1961).

    Article  CAS  PubMed  Google Scholar 

  16. P. Lallouette, B. Bizzini and M. Raynaud, Nouv. Génie méd.25, 13 (1975).

    Google Scholar 

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Authors and Affiliations

  1. Service de Pathologie cellulaire et Cancérologie, Hôpital Marie Lannelongue, 133 avenue de la Résistance, F-92350, Le Plessis Robinson, France

    K. H. Hollmann & J. M. Verley

Authors
  1. K. H. Hollmann
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  2. J. M. Verley
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Additional information

This work was partly supported by a contract from CHU Necker Enfants Malades (Prof. J. Reynier), with the help of the Ligue Nationale Française contre le Cancer, the FEGE-FLUC and the International Society against Breast Cancer.

We thank also the Ecole de Chirurgie, Paris, and the Pasteur Institute which kindly provided the immunostimulating agent P 40. The skillfull collaboration of Dr R. Villet, Mlle G. Amichot and Mme J. Garaudel is gratefully acknowledged.

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Hollmann, K.H., Verley, J.M. Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma. Experientia 36, 1213–1215 (1980). https://doi.org/10.1007/BF01976136

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