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Angiotensin II in the hippocampus. A histochemical and electrophysiological study

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Summary

The presence of the renin angiotensin system in the hippocampus is shown by immunohistochemistry. Intra- and extra-cellular recordings revealed that angiotensin II and III excite CA 1 pyramidal cells by disinhibition. The effect is antagonized by [Sar1, Thr8]-A II.

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Author notes

  1. D. Felix

    Present address: Institute of Brain Research, University of Zürich, Zürich, Switzerland

  2. M. R. Celio

    Present address: Institute of Anatomy, University of Zürich, Zürich, Switzerland

  3. T. Inagami

    Present address: Department of Biochemistry, Vanderbilt University, Nashville, USA

Authors and Affiliations

  1. Neurophysiology Laboratory, Neurochirurgische Universitätsklinik, CH-8091, Zürich, Switzerland

    H. L. Haas, D. Felix, M. R. Celio & T. Inagami

Authors
  1. H. L. Haas
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  2. D. Felix
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  3. M. R. Celio
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  4. T. Inagami
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Additional information

This work was supported by grant Nos 3.271.78 and 3.396.78 of the Swiss National Science Foundation and research grant HL-24112 from NIH. T. Inagami was a visiting scientist of the Roche Medical Research Foundation.

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Haas, H.L., Felix, D., Celio, M.R. et al. Angiotensin II in the hippocampus. A histochemical and electrophysiological study. Experientia 36, 1394–1395 (1980). https://doi.org/10.1007/BF01960117

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  • DOI: https://doi.org/10.1007/BF01960117

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