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Effects of angiotensin II and of an angiotensin II receptor antagonist on Simian virus 40-induced tumor growth in vivo

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Summary

The effects of angiotensin II and of the competitive angiotensin II receptor antagonist saralasin on in vivo tumor growth were investigated in hamsters. Angiotensin II strongly inhibited tumor growth while saralasin stimulated it, though the high dose used had partial agonistic angiotensin II-like actions. Lower doses of saralasin were without significant effect on tumor weights.

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Authors and Affiliations

  1. Department of Pharmacology, University of Heidelberg, D-6900, Heidelberg, Federal Republic of Germany

    P. Schelling, D. Ganten, Z. Nemes & H. Fischer

  2. Institut for Virus Research, German Cancer Research Center, D-6900, Heidelberg, Federal Republic of Germany

    P. Schelling, D. Ganten, Z. Nemes & H. Fischer

  3. Chemin de Musée, Institut de Recherche Cardio-Angéiologique, CH-1700, Fribourg, Switzerland

    P. Schelling

Authors
  1. P. Schelling
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  2. D. Ganten
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  3. Z. Nemes
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  4. H. Fischer
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Additional information

Acknowledgments. These studies were supported by the Deutsche Forschungsgemeinschaft (DFG) within the SFB 90 ‘Cardiovaskuläres System’. Saralasin was a gift from Dr A.W. Castellion, Norwich Pharmacal Company, USA. We thank S. Thiele, P. Baumgärtl and D. Kurz for excellent technical assistance.

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Schelling, P., Ganten, D., Nemes, Z. et al. Effects of angiotensin II and of an angiotensin II receptor antagonist on Simian virus 40-induced tumor growth in vivo. Experientia 36, 452–454 (1980). https://doi.org/10.1007/BF01975143

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  • DOI: https://doi.org/10.1007/BF01975143

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