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Structure and toxicity of the alkaloids of Russian comfrey (Symphytum x uplandicum Nyman), a medicinal herb and item of human diet

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Summary

Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves ofSymphytum × uplandicum The combined alkaloids exhibit chronic hepatotoxicity in rats.

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Literatur

  1. L.D. Hills, Comfrey, Past, Present and Future. Faber and Faber, London 1976.

    Google Scholar 

  2. H.E. Kirschner, Nature's Healing Grasses. H. C. White Publications, Riverside 1960.

    Google Scholar 

  3. L.B. Bull, C.C.J. Culvenor and A.T. Dick, The Pyrrolizidine Alkaloids. North-Holland, Amsterdam 1968, a) p. 234, b) p. 143, c) p. 163.

    Google Scholar 

  4. C.C.J. Culvenor and L.W. Smith, Aust. J. Chem.8, 556 (1955).

    Article  CAS  Google Scholar 

  5. E. Pedersen, Arch. Pharm. Chem. sci. Ed.3, 55 (1975).

    CAS  Google Scholar 

  6. T. Furuya and K. Araki, Chem. pharm. Bull., Japan16, 2512 (1968).

    Article  CAS  Google Scholar 

  7. T. Furuya and M. Hikichi, Phytochemistry10, 2217 (1971).

    Article  CAS  Google Scholar 

  8. M.E. Fowler and R. Schoental, J. Am. vet. med. Ass.150, 1305 (1967).

    Google Scholar 

  9. R. Schoental, M.E. Fowler and A. Coady, Cancer Res.30, 2127 (1970).

    CAS  PubMed  Google Scholar 

  10. C.C.J. Culvenor, J.A. Edgar, M.V. Jago, A. Outteridge, J.E. Peterson and L.W. Smith, Chemico-Biol. Interact.12, 299 (1976).

    Article  CAS  Google Scholar 

  11. M.V. Jago, Aust. J. exp. Biol. med. Sci.48, 93 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. E. McLean, Pharmac. Rev.22, 429 (1970).

    CAS  Google Scholar 

  13. O. Mohabbat, R.N. Srivastava, M.S. Younos, G.G. Sediq, A.A. Merzad and G.N. Aram, Lancet2, 269 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. B.N. Tandon, R.K. Tandon, H.D. Tandon, M. Narndranathan and Y.K. Joshi, Lancet2, 271 (1976).

    Article  CAS  PubMed  Google Scholar 

  15. P.T. Hooper and W.A. Scanlan, Aust. vet. J.53, 109 (1977).

    Article  CAS  PubMed  Google Scholar 

  16. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, vol. 10. International Agency for Research on Cancer, Lyon 1976.

  17. National Cancer Institute. Bioassay of Lasiocarpine for Possible Carcinogenesis, Technical report No. 39, DHEW (NIH). 78-839, Bethesda, Maryland 1978.

  18. M.V. Jago and J.E. Peterson, unpublished data.

  19. A. Saifer and T. Marven, Clin. Chem.12, 414 (1966).

    Article  CAS  PubMed  Google Scholar 

  20. Anon, Z. klin. Chem. klin. Biochem.8, 658 (1970).

  21. I. Hirono, H. Mori and M. Haga, J. nat. Cancer Inst.61, 865 (1978); I. Hirono, personal communication.

  22. R. Schoental, J. Path.77, 485 (1959).

    Article  CAS  Google Scholar 

  23. M.V. Jago, Aust. J. exp. Biol. med. Sci.48, 94 (1970).

    Article  Google Scholar 

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Authors and Affiliations

  1. CSIRO, Division of Animal Health, Private Bag 1, 3052, Parkville, Victoria, Australia

    C. C. J. Culvenor, M. Clarke, J. A. Edgar, J. L. Frahn, M. V. Jago, J. E. Peterson & L. W. Smith

Authors
  1. C. C. J. Culvenor
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  2. M. Clarke
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  3. J. A. Edgar
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  4. J. L. Frahn
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  5. M. V. Jago
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  6. J. E. Peterson
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  7. L. W. Smith
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Additional information

The authors thank N. Anderton and P. Stewart for skilled assistance and V. Lord for statistical analyses.

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Culvenor, C.C.J., Clarke, M., Edgar, J.A. et al. Structure and toxicity of the alkaloids of Russian comfrey (Symphytum x uplandicum Nyman), a medicinal herb and item of human diet. Experientia 36, 377–379 (1980). https://doi.org/10.1007/BF01975096

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  • DOI: https://doi.org/10.1007/BF01975096

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