Summary
In KB cells, MRC5 and adult skin fibroblasts infected by low doses of Sendaï virus, intracellular cyclic AMP levels rose and fell in the first hours following infection, then remained lower than basal level during at least 2 days in KB cells and adult skin fibroblasts. When compared to other viruses or cAMP inducers previously described, this effect appeared specific of Sendaï virus. Mechanisms and roles of cAMP variations are discussed. VSV-infected KB cells showed slightly decreased cAMP levels during the first hours following infection.
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Ce travail a bénéficié de l'aide du CNRS (RCP No. 08533) et d'une aide aux équipes de Jeunes Chercheurs de la Mission à la Recherche du Ministère des Universités (bénéficiaire J. Farjanel).
Les auteurs remercient Madame le Professeur O. Gaudin pour ses conseils et ses encouragements.
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Vallier, P., Farjanel, J., Bata, J. et al. Variations des concentrations de cAMP intracellulaire de différents types de cellules après infection par le virus Sendaï ou le virus de la stomatite vésiculeuse. Experientia 37, 21–23 (1981). https://doi.org/10.1007/BF01965546
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DOI: https://doi.org/10.1007/BF01965546