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The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep

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Summary

The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b. wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs. The results were: longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep. Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated. The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.

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Authors and Affiliations

  1. Psychiatric Clinic, Research Department/Sleep Laboratories, CH-5200, Königsfelden, Switzerland

    D. Schneider-Helmert & G. A. Schoenenberger

  2. Research Division, Department of Surgery/Research Department Kantonsspital, University of Basel, CH-4031, Basel, Switzerland

    D. Schneider-Helmert & G. A. Schoenenberger

Authors
  1. D. Schneider-Helmert
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  2. G. A. Schoenenberger
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Additional information

In honor of W. R. Hess, to mark the centenary of his birth.

Editorial foreword. Experimental work in the field of sleep research was energetically furthered by the efforts of the eminent physiologist and Nobel Laureate Walter Rudolf Hess, in whose memory the Zürich lecture series ‘The Principle of Order in Physiology’ was held on March 14th, 1981. The following report documents the first controlled clinical experiments testing the delta-sleep-inducing-peptide on chronic sufferers of insomnia. In order that these findings may reach as wide a readership as possible, we are placing this brief but important report under the heading ‘Generalia’.

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Schneider-Helmert, D., Schoenenberger, G.A. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia 37, 913–917 (1981). https://doi.org/10.1007/BF01971753

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