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Inhibition of neurotensin (NT)-induced glucagon release by [D-Trp11]-NT1

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Summary

A synthetic analog of neurotensin (NT), [D-Trp11]-NT, antagonized NT-induced hyperglucagonemia and hyperglycemia, and also NT-induced glucagon release from pancreatic islets in rats.

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Authors and Affiliations

  1. Institute of Germfree Life Researc, Nagoya University School of Medicine, Showa-ku, 466, Nagoya, Japan

    M. Ukai, T. Itatsu, A. Shibata, F. Rioux & S. St-Pierre

  2. Department of Physiology and Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    M. Ukai, T. Itatsu, A. Shibata, F. Rioux & S. St-Pierre

Authors
  1. M. Ukai
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  2. T. Itatsu
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  3. A. Shibata
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  4. F. Rioux
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  5. S. St-Pierre
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Additional information

This work was supported in part by a grant from the Imanaga Medical Research Foundation, Nagoya, Japan. Address for reprint requests: M.U., Department of Surgery, National Nagoya Railway Hospital, Taiko 1-chome, Nakamura-ku, Nagoya 453, Japan.

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Ukai, M., Itatsu, T., Shibata, A. et al. Inhibition of neurotensin (NT)-induced glucagon release by [D-Trp11]-NT1. Experientia 38, 1222–1224 (1982). https://doi.org/10.1007/BF01959752

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  • DOI: https://doi.org/10.1007/BF01959752

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