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Reversible depression of spontaneous brain electrical activity induced by actinomycin D and 7-aminoactinomycin D in rats

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  • Physiology, Pathophysiology
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Summary

Various types of actinomycin (C, D, S2, I and V) and 7-amino-analogue of actinomycin D were injected into the right lateral ventricle of the brain through a chronically implanted cannula. In rats but not in mice actinomycin D, actinomycin S2 and 7-aminoactinomycin D caused depression of EEG, while cardiac and respiratory activity were maintained. This effect of the EEG was reversible and a normal EEG pattern reappeared at least 3 h after administration.

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References

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Authors and Affiliations

  1. Department of Physiology, Okayama University Medical School, 700, Okayama, Japan

    E. Uezu, Y. Takada & N. Mishima

  2. Department of Biological Science, Faculty of Pharmacology, Tokushima Bunri University, 770, Tokushima, Japan

    E. Uezu, Y. Takada & N. Mishima

Authors
  1. E. Uezu
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  2. Y. Takada
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  3. N. Mishima
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Uezu, E., Takada, Y. & Mishima, N. Reversible depression of spontaneous brain electrical activity induced by actinomycin D and 7-aminoactinomycin D in rats. Experientia 38, 1446–1447 (1982). https://doi.org/10.1007/BF01955760

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  • DOI: https://doi.org/10.1007/BF01955760

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