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3,5-Dibromo-2′-chloro-4′-isothiocyanatosalicylanilide, a potent anthelminitic

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Summary

The compound, 3,5-dibromo-2′-chloro-4′-isothiocyanatosalicylanilide, has been tested against various nematode and cestode parasites in experimental and domestric animals. It shoved 100% activity againstAncylostoma ceylanicum, A. tubaeformis, Syphacia obvelata, Ascaridia galli, Toxocara spp.,Toxascaris sp.,Gnathostoma spinigerum, Hymenolepis nana, Raillietina spp. andTaenia spp. in doses 25–70 mg/kg given in single or multiple administrations.

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Authors and Affiliations

  1. Division of Parasitology and Divison of Medicinal Chemistry, Central Drug Research Institute, 226001, Lucknow, India

    J. C. Katiyar, P. K. S. Visen, S. Gupata, A. B. Sen, S. K. Dubey & Satyavan Sharma

Authors
  1. J. C. Katiyar
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  2. P. K. S. Visen
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  3. S. Gupata
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  4. A. B. Sen
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  5. S. K. Dubey
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  6. Satyavan Sharma
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Additional information

Acknowledgments. We express sincere thanks to Dr Nitya Nand, F.N.A., CDRI, Lucknow, for his keen interest in the work, to Dr B. N. Dhawan, F.N.A. for providing informations about general pharmacology of the compound, and to Dr R. K. Chatterjee and Dr P. K. Murthy for carrying out antifilarial sreening. Technical assistance of Mr S. C. Bhar and Mr S. Ram is acknowledged.

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Katiyar, J.C., Visen, P.K.S., Gupata, S. et al. 3,5-Dibromo-2′-chloro-4′-isothiocyanatosalicylanilide, a potent anthelminitic. Experientia 38, 457–460 (1982). https://doi.org/10.1007/BF01952636

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