Summary
Compared to control, kidney slices from rats undergoing glycerol-induced ATN produce less ammonia from glutamate, but show no difference when glutamine is substrate. However, gluconeogenesis from glutamine, like glutamate, is decreased in acute tubular necrosis (ATN). We conclude that renal ammoniagenesis is influenced by ATN. Glycerol-induced ATN causes a relative increase in glutamine deamidation and a decrease in glutamate deamination.
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Supported by a grant from the American Kidney Fund.
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Preuss, H.G., Sundquist, R. & Podlasek, S.J. Renal ammoniagenesis in kidney slices from rats undergoing glycerol-induced acute tubular necrosis. Experientia 38, 678 (1982). https://doi.org/10.1007/BF01964090
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DOI: https://doi.org/10.1007/BF01964090