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On the role of carbonic anhydrase in the anticonvulsant effects of triethyltin (TET)

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Summary

Triethyltin (TET) and acetazolamide (ACTZ) both produce marked anticonvulsant effects as evaluated by the maximal electroshock seizure test. However, the mechanism responsible for the anticonvulsant effect of TET and ACTZ is probably not the same since TET does not inhibit the activity of carbonic anhydrase isozyme C in vitro.

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This study was supported by NIEHS Toxicology Training grant No. ES07 090, NIOSH grant No. OH07085 and a University of Texas Biomedical Research grant. We wish to thank Rebecca Crenshaw for her excellent technical assistance.

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Doctor, S.V., Fox, D.A. On the role of carbonic anhydrase in the anticonvulsant effects of triethyltin (TET). Experientia 38, 824–826 (1982). https://doi.org/10.1007/BF01972294

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