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Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines

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Summary

The specific benzodiazepine antagonist, Ro 15-1788, elicited withdrawal symptoms in squirrel monkeys, cats, rats and mice made tolerant and physically dependent by subchronic administration of high doses of diazepam, lorazepam or triazolam.

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References

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Authors and Affiliations

  1. Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd, CH-4002, Basel, Switzerland

    R. Cumin, E. P. Bonetti, R. Scherschlicht & W. E. Haefely

Authors
  1. R. Cumin
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  2. E. P. Bonetti
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  3. R. Scherschlicht
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  4. W. E. Haefely
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Cumin, R., Bonetti, E.P., Scherschlicht, R. et al. Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines. Experientia 38, 833–834 (1982). https://doi.org/10.1007/BF01972300

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  • DOI: https://doi.org/10.1007/BF01972300

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