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Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations

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Summary

In rats, chronic infusion of α-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined. There were no gross pharmacological effects associated with this depletion.

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References

  1. Shepherd, D. M., and Mackay, D., Prog. med. Chem.5 (1967) 199.

    Article  CAS  PubMed  Google Scholar 

  2. Beaven, M. A., Monographs in Allergy, vol. 13. Eds P. Dukor, P. Kallos, Z. Trnka, B. H. Waksman and A. L. De Weck. Karger, Basel/New York 1978.

    Google Scholar 

  3. Kollonitsch, J., Patchett, A. A., Marburg, S., Maycock, A. L., Perkins, L. M., Doldouras, G. A., Duggan, D. E., and Aster, S. D., Nature, Lond.274 (1978) 906.

    Article  CAS  PubMed  Google Scholar 

  4. Garbarg, M., Barbin, E., Rodergas, E., and Schwartz, J. C., J. Neurochem.35 (1980) 1045.

    Article  CAS  PubMed  Google Scholar 

  5. Maeyama, K., Watanabe, T., Taguchi, Y., Yamatodani, A. and Wada, H., Biochem. Pharmac.31 (1982) 2367.

    Article  CAS  Google Scholar 

  6. Bouclier, M., Jung, M. J., and Gerhart, F., Biochem. Pharm.32 (1983) 1553.

    Article  CAS  PubMed  Google Scholar 

  7. Bouclier, M., Jung, M. J., and Gerhart, F., Agents Action13 (1983) 241.

    Article  CAS  Google Scholar 

  8. Taylor, K., and Snyder, S. H., J. Neurochem.19 (1972) 1343.

    Article  CAS  PubMed  Google Scholar 

  9. Baudry, M., Martres, M. P., and Schwartz, J. C., J. Neurochem.21 (1973) 1301.

    Article  CAS  PubMed  Google Scholar 

  10. Taylor, K., and Snyder, S. H., J. Neurochem.19 (1972) 341.

    Article  CAS  PubMed  Google Scholar 

  11. Verdiere, M., Rose, C., and Schwartz, J. C., Brain Res.129 (1977) 107.

    Article  CAS  PubMed  Google Scholar 

  12. Beaven, M. A., Horakova, Z., Severs, W. B., and Brodie, B. B., J. Pharmac. exp. Ther.161 (1968) 320.

    CAS  Google Scholar 

  13. Schayer R. W., in: Mechanism of hypersensitivity, p. 227. Little Brown, Boston 1959.

    Google Scholar 

  14. Schwartz, J. C., Rev. Pharmac. Tox.17 (1977) 325.

    Article  CAS  Google Scholar 

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Author notes

  1. M. J. Jung

    Present address: Centre de Recherche Merrell International, 16 rue d'Ankara, F-67084, Strasbourg Cedex, France

Authors and Affiliations

  1. Centre de Recherche Merrell International, 16 rue d'Ankara, F-67084, Strasbourg Cedex, France

    M. Bouclier & F. Gerhart

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  1. M. Bouclier
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  2. M. J. Jung
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  3. F. Gerhart
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Bouclier, M., Jung, M.J. & Gerhart, F. Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations. Experientia 39, 1303–1305 (1983). https://doi.org/10.1007/BF01990382

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  • DOI: https://doi.org/10.1007/BF01990382

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