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Continued in vitro and in vivo release of an antitumor drug from albumin microspheres

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Summary

Heated albumin microspheres with an average diameter of 45±8 μm and containing mitomycin C, released, in vitro, about 20% of this antibiotic over a 3-day period. VX-2 tumors were implanted into the hind leg of rabbits and the drug-containing microspheres were injected into the femoral artery of these animals. High levels of the drug were maintained for several hours in the tumor and growth of the tumor was inhibited considerably, compared to findings in control rabbits given the conventional mitomycin C. Half the number of the rabbits treated with our new method are alive with no evidence of tumor.

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References

  1. Sugibayashi, K., Morimoto, Y., Nadai, T., Kato, Y., Hasegawa, A., and Arita, T., Chem. Pharm. Bull.27 (1979) 204.

    Article  CAS  Google Scholar 

  2. Sugibayashi, K., Akimoto, M., Morimoto, Y., Nadai, T., and Kato, Y., J. Pharm. Dyn.2 (1979) 350.

    Article  CAS  Google Scholar 

  3. Morimoto, Y., Sugibayashi, K., Okumura, M., and Kato, Y., J. Pharm. Dyn.3 (1980) 264.

    Article  CAS  Google Scholar 

  4. Morimoto, Y., Sugibayashi, K., and Kato, Y., Chem. Pharm. Bull.29 (1981) 1433.

    Article  CAS  Google Scholar 

  5. Kato, T., Nemoto, R., Mori, H., Mori, H., and Kumagai, I., Cancer46 (1980) 14.

    Article  CAS  PubMed  Google Scholar 

  6. Scheffel, U., Rhodes, B.A., Natarajan, T.K., and Wagner, Jr., H.N., J. nucl. Med.13 (1972) 498.

    CAS  PubMed  Google Scholar 

  7. Fujita, H., Cancer Chemother1 (1974) 497.

    Google Scholar 

  8. Ovejera, A.A., Houchens, D.P., and Barker, A.D., Ann. clin. Lab. Sci.8 (1978) 50.

    CAS  PubMed  Google Scholar 

  9. Abboud, F.M., Schmid, P.G., Heistad, D.D., and Mark, A.L., in: Clinical cardiovascular physiology, p. 143. Ed. H.J. Levine. Grune & Stratton, Inc., New York/San Francisco/London 1976.

    Google Scholar 

  10. Wallace, S., Granmayeh, M., DeSantos, L.A., Murray, J.A., Romsdahl, M.M., Bracken, R.B., and Jonsson, K., Cancer43 (1979) 322.

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. Y. Morimoto & K. Sugibayashi

    Present address: Faculty of Pharmaceutical Sciences, Josai University, Sakado, Sartama, Japan

  2. A. Miyakawa & H. Suzuki

    Present address: Professional Relations Department, Kyowa Hakko Co. Ltd, Tokyo, Japan

Authors and Affiliations

  1. The First Department of Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, 280, Chiba, Japan

    S. Fujimoto, F. Endoh, Y. Kitsukawa, K. Okui, Y. Morimoto, K. Sugibayashi, A. Miyakawa & H. Suzuki

Authors
  1. S. Fujimoto
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  2. F. Endoh
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  3. Y. Kitsukawa
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  4. K. Okui
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  5. Y. Morimoto
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  6. K. Sugibayashi
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  7. A. Miyakawa
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  8. H. Suzuki
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Additional information

We thank M. Ohara for reading the manuscript.

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Fujimoto, S., Endoh, F., Kitsukawa, Y. et al. Continued in vitro and in vivo release of an antitumor drug from albumin microspheres. Experientia 39, 913–916 (1983). https://doi.org/10.1007/BF01990435

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  • DOI: https://doi.org/10.1007/BF01990435

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