Skip to main content
SpringerLink
Log in

Analgesic activity of certain tripeptide-β-phenethylamide analogs

  • Short Communications
  • Pharmacology, Toxicology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Studies of the analgesic effect of tripeptide-β-phenethylamides are described, and their structure-activity relationship is discussed. SD-25, which has a methyl group at R2, and a hydroxymethyl group at R3 of β-phenethylamide, was the most potent one of the 8 analogs tested.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A., and Morris, H.R., Nature258 (1975) 577.

    Article  CAS  PubMed  Google Scholar 

  2. Roemer, D., Buescher, H.H., Hill, R.C., Pless, J., Bauer, W., Cardinaux, F., Closse, A., Hauser, D., and Huguenin, R., Nature268 (1977) 547.

    Article  CAS  PubMed  Google Scholar 

  3. Bajusz, S., Rónai, A.Z., Székely, J.I., Gráf, L., D-Kovács, Z., and Berzetei, I., FEBS Lett.76 (1977) 91.

    Article  CAS  PubMed  Google Scholar 

  4. Woolfe, G., and MacDonald, A.D., J. Pharmac. exp. Ther.80 (1944) 300.

    CAS  Google Scholar 

  5. Litchfield, Jr, J.T., and Wilcoxon, F., J. Pharmac. exp. Ther.96 (1949) 99.

    CAS  Google Scholar 

  6. Koster, R., Anderson, M., and de Beer, E.J., Fedn Proc.18 (1959) 412.

    Google Scholar 

  7. Pless, J., Bauer, W., Cardinaux, F., Closse, A., Hauser, D., Huguenin, R., Roemer, D., Buescher, H.-H., and Hill, R.C., Helv. chim. Acta62 (1979) 398.

    Article  CAS  Google Scholar 

  8. Roemer, D., and Pless, J., Life Sci.24 (1979) 621.

    Article  CAS  PubMed  Google Scholar 

  9. Morley, J.S., A. Rev. Pharmac. Tox.20 (1980) 81.

    Article  CAS  Google Scholar 

  10. McGregor, W.H., Stein, L., and Belluzzi, J.D., Life Sci.23 (1978) 1371.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan

    C. Kamei, M. Mio & K. Tasaka

Authors
  1. C. Kamei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Mio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Tasaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. A series of SD- and OE-compounds were kindly provided by Earth Chemical Co., Ltd, Ako, Hyogo (Japan). To whom reprint requests should be addressed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kamei, C., Mio, M. & Tasaka, K. Analgesic activity of certain tripeptide-β-phenethylamide analogs. Experientia 39, 1025–1026 (1983). https://doi.org/10.1007/BF01989784

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01989784

Keywords

Search

Navigation