Summary
The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.
This is a preview of subscription content, log in via an institution to check access.
References
Walker, A.W., Clinica chim. Acta55 (1974) 399.
De Broe, M.E., Bosteels, V., and Wieme, R.J., Lancet1 (1974) 753.
Štěpán, J., and Pilařová, T., Lancet1 (1975) 1188.
Štěpán, J., Volek, V., and Kolář, J., Clinica chim. Acta69 (1976) 1.
Gindler, E., and King, J.D., Am. J. clin. Path.58 (1972) 376.
Heinonen, J.K., and Lahti, R.J., Analyt. Biochem.113 (1981) 313.
Dixon, W.J., BMDP Biomedical Computer Programs. University of California Press, Berkeley and Los Angeles 1976.
Meijer, D.K.F., Scholtens, H.B., and Hardonk, M.J., Pharm. Weekbl. Ned.4 (1982) 57.
Marshall, J.S., and Williams, S., Biochim. biophys. Acta543 (1978) 41.
Stolbach, L.L., Krant, M.J., Inglis, N.I., and Fishman, W.H., Gastroenterology52 (1967) 819.
Blomhoff, R., Tolleshaug, H., and Berg, T., J. biol. Chem.257 (1982) 7456.
Birge, S.J., and Gilbert, H.R., J. clin. Invest.54 (1974) 710.
Lecchi, C., De Bastiani, G., and Zatti, M., clinica chim. Acta57 (1974) 171.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Štěpán, J., Harvránck, T., Jelínková, E. et al. Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure. Experientia 40, 517–518 (1984). https://doi.org/10.1007/BF01952416
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01952416