Summary
Δ 1-Tetrahydrocannabinol (Δ 1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ngΔ 1-THC/mg membrane protein (10−5 M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.
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This work was supported by grants from the Medical Research Council, the Wellcome Trust and the E. P. Abraham Cephalosporin Trust
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Leuschner, J.T.A., Wing, D.R., Harvey, D.J. et al. The partitioning ofΔ1-tetrahydrocannabinol into erythrocyte membranes in vivo and its effect on membrane fluidity1into erythrocyte membranes in vivo and its effect on membrane fluidity1. Experientia 40, 866–868 (1984). https://doi.org/10.1007/BF01951999
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DOI: https://doi.org/10.1007/BF01951999