Summary
Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide α-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.
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References
Yoder, O. C., A. Rev. Phytopath.18 (1980) 103.
Scheffer, R. P., and Ullstrup, A. J., Phytopathology55 (1965) 1037.
Ullstrup, A. J., and Brunson, A. M., J. Am. Soc. Agron.39 (1947) 606.
Abbreviations: Aib=aminoisobutyric acid; Ala=alanine; Ile=isoleucine; Leu=leucine; Phe=phenylalanine; Pip=pipecolic acid; Pro=proline; Tyr=tyrosine.
Walton, J. D., Earle, E. D., and Gibson, B. W., Biochem. biophys. Res. Commun.107 (1982) 785.
Kawai, M., Rich, D. H., and Walton, J. D., Biochem. biophys. Res. Commun.111 (1983) 398.
Barron, G. L., and Onions, A. H. S., Can. J. Bot.44 (1966) 861.
Closse, A., and Huguenin, R., Helv. chim. Acta57 (1974) 533.
Stähelin, H., and Trippmacher, A., Eur. J. Cancer10 (1974) 801.
Kawai, M., and Rich, D. H., Tetrahedron Lett.24 (1983) 5309.
Rich, D. H., and Gardner, J. H., Tetrahedron Lett.24 (1983) 5305.
Hirota, A., Suzuki, A., Suzuki, H., and Tamura, S., Agric. biol. Chem.37 (1973) 643.
Hirota, A., Suzuki, A., Aizawa, K., and Tamura, S., Biomed. Mass Spectom.1 (1974) 15.
Grieder, A., Maurer, R., and Stähelin, H., Cancer Res.37 (1977) 2998.
Shurtleff, M. C., Compendium of corn diseases, 2nd edn. Am. Phytopath. Soc., St. Paul 1980.
Index of plant diseases in the United States, Agr. Handbook No. 165, Agr. Res. Service, U.S. Dept. Agr., Washington D.C. 1960.
Grieder, A., Schleisner, P., and Maurer, R., in: Pulse-Cytophotometry, part 2, p. 161. Eds C.A.M. Haanen, H.F.P. Hillen and J.M.C. Wessels. 1975.
Walton, J. D., and Earle, E. D., Physiol. Plant Path.22 (1983) 371.
Earle, E. D., and Gracen, V. E., in: Plant tissue culture 1982, p. 663. Ed. A. Fujiwara. Jap. Assoc. Plant Tisue culture, Tokyo 1982.
Rich, D. H., Kawai, M., and Jasensky, R. D., Int. J. Peptide Protein Res.21 (1983) 35.
Rich, D. H., Bhatnagar, P. K., Jasensky, R. D., Steele, J. A., Uchytil, T. F., and Durbin, R. D., Bioorg. Chem.7 (1978) 207.
Yasutake, A., Lee, S., Aoyagi, H., Kato, T., and Izumiya, N., Chem. Lett.1978 875.
Kuo, M., Yoder, O. C., and Scheffer, R. P., Phytopathology60 (1970) 365.
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Walton, J.D., Earle, E.D., Stähelin, H. et al. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia 41, 348–350 (1985). https://doi.org/10.1007/BF02004498
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DOI: https://doi.org/10.1007/BF02004498