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Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis

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The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methyl-coumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases.

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Iwase-Okada, K., Kojima, K., Kato, T. et al. Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis. Experientia 41, 487–488 (1985). https://doi.org/10.1007/BF01966162

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  • DOI: https://doi.org/10.1007/BF01966162

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