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Naloxone prevents the analgesic action of α-MSH in mice

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

α-MSH (0.1, 1, 10 μg) was administered intracerebroventricularly and its action on pain sensitivity was investigated by the hot-plate method in mice. α-MSH produced dose-dependent analgesia and this analgesic effect was prevented by naloxone (1 mg/kg, s.c.). It is possible that α-MSH may play a role in the mechanism of pain through endogeneous opioid systems.

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Authors and Affiliations

  1. Department of Pharmacology, Fukuoka Dental College, Sawara-ku, 814-01, Fukuoka, Japan

    T. Ohkubo, M. Shibata, H. Takahashi & S. Naruse

Authors
  1. T. Ohkubo
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  2. M. Shibata
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  3. H. Takahashi
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  4. S. Naruse
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Ohkubo, T., Shibata, M., Takahashi, H. et al. Naloxone prevents the analgesic action of α-MSH in mice. Experientia 41, 627–628 (1985). https://doi.org/10.1007/BF02007691

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  • DOI: https://doi.org/10.1007/BF02007691

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