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Tyrosinase-cytalyzed conjugation of dopa with glutathione

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Summary

A convenient method is described for the preparation of 5-S- and 2-S-glutathionyldopa, based on tyrosinase oxidation of dopa in the presence of glutathione. The yields of 5-S, 2-S, and 6-S isomers produced were about 76, 12, and 5%, respectively.

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Authors and Affiliations

  1. Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University, 470-11, Toyoake, Aichi, Japan

    S. Ito, A. Palumbo & G. Prota

  2. Stazione Zoologica di Napoli, 80121, Napoli, Italy

    S. Ito, A. Palumbo & G. Prota

Authors
  1. S. Ito
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  2. A. Palumbo
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  3. G. Prota
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Additional information

One of the authors (G.P.) thanks the C.N.R. (P.F. Chimica Fine e Secondaria) for partial financial support.

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Ito, S., Palumbo, A. & Prota, G. Tyrosinase-cytalyzed conjugation of dopa with glutathione. Experientia 41, 960–961 (1985). https://doi.org/10.1007/BF01970033

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  • DOI: https://doi.org/10.1007/BF01970033

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