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Cortisol and immune interferon can interact in the modulation of human natural killer cell activity

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Summary

This paper reports that cortisol at physiological concentrations minimizes the enhancement of human natural killer (NK) cell activity in vitro by immune interferon (IFN-γ). This effect may be important for the regulation of NK cytotoxicity in vivo.

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Authors and Affiliations

  1. Istituto di Medicina Interna, Cattedra di Patologia Medica D, Università di Torino, Strada S. Vito, 34, I-10133, Torino, Italy

    R. Cavallo, M. L. Sartori, G. Gatti & A. Angeli

Authors
  1. R. Cavallo
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  2. M. L. Sartori
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  3. G. Gatti
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  4. A. Angeli
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Additional information

This work was supported by grants from National Research Council (CNR No. 84. 00425.44) and from Regione Piemonte, Assessorato alla Sanità, Special Project No. 31.

Acknowledgments. The authors wish to acknowledge their gratitude to Prof. F. Dianzani (Institute of Virology, University of Rome) for having provided IFN preparations and Dr S. Landolfo (Institute of Microbiology, University of Turin) for his critical review of this manuscript.

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Cavallo, R., Sartori, M.L., Gatti, G. et al. Cortisol and immune interferon can interact in the modulation of human natural killer cell activity. Experientia 42, 177–179 (1986). https://doi.org/10.1007/BF01952455

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  • DOI: https://doi.org/10.1007/BF01952455

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