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Alopecia induced in young mice by exposure to excess dietary zinc

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Second generation mice were exposed to normal (50 ppm, Group I) or excess (2000 ppm, Group II) zinc in the maternal diet during gestation and lactation, then weaned and continued on the mother's diet until sacrifice at 8 weeks. Tibia zinc reflected dietary intake. Group II had reduced plasma copper, body weight, and hematocrit; the second coat of hair appeared late and was lighter in color than Group I, possibly as an effect of copper and pigmentation development and hair growth.

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References

  1. Porter, K. G., McMaster, D., Elmes, m. E., and Love, A. H. G., LancetII (1977) 2774.

    Google Scholar 

  2. Hoogenraad T. U., Van Den Hamer, C. J. A., Koevoet, R., and Korver, E. G. M., LancetII (1978) 1262.

    Article  Google Scholar 

  3. Bremmer, B. I., Young, B. W., and Mills, C. F., Br. J. Nutr.36 (1976) 551.

    Article  Google Scholar 

  4. Smith, W. H., Plumlee, M. P., and Beeson, W. M., Science128 (1958) 1280.

    Article  CAS  PubMed  Google Scholar 

  5. National Research Council, Nutrient Requirments of Laboratory Animals, pp. 38–53. National Academy of Sciences, Washington, DC. 1978.

    Google Scholar 

  6. Stroube, W. B., Cunningham, W. C., Tanner, J. T., Bradley, B. D., and Gaylor, G., J. Radioanalyt. Chem.69 (1982) 453.

    Article  CAS  Google Scholar 

  7. Marston, H. R., Physiol. Rev.32 (1952) 66.

    Article  CAS  PubMed  Google Scholar 

  8. Menkes, J. H., Alter, M., Steigleder, G. K., Weakley, D. R., and Sung, J. H., Pediatrics29 (1962) 764.

    CAS  PubMed  Google Scholar 

  9. Obeck, D. K., Lab. Anim., Sci.28 (1978) 698.

    CAS  PubMed  Google Scholar 

  10. Bleavins, M. R., Aulerich, R. J., Hochstein, J. R., Hornshaw, T. C., and Napolitano, A. C., N. Nutr.113 (1983) 2360.

    CAS  Google Scholar 

  11. Underwood, E. J., Trace Elements in Human and Animal Nutrition, 4th edn, p. 80. Academic Press, New York 1977.

    Google Scholar 

  12. Evans, G. W., Grace, C. I., and Votava, H. J., Am. J. Physiol.228 (1975) 501.

    Article  CAS  PubMed  Google Scholar 

  13. Reeves, J. R. T., and Maibach, H. I., in: Advances in Modern Toxicology, vol. 4, p. 487. Eds F. N. Marzulli and H. I. Maibach. Hemisphere, Washington, DC 1977.

    Google Scholar 

  14. Pierard, G. E., J. cutan Path.6 (1979) 237.

    Article  CAS  PubMed  Google Scholar 

  15. Metter, D., and Vock, R., Z. Rechtsmed.91 (1984) P201.

    Article  Google Scholar 

  16. Clercq, E. D., Descamps, J., Somer, P. D., Samyn, C., and Smets, G., Experientia36 (1980) 1197.

    Article  Google Scholar 

  17. Lee, K. P., Terrill, J. B., and Henry, N. W., J. Toxic. envir. Hlth3 (1977) 859.

    Article  CAS  Google Scholar 

  18. Chanda, J. J., Anderson, H. A., Glamb, R. W., Lomatch, D. L., Wolff, M. S., Voorhees, J. J., and Selikoff, I. J., Envir. Res.29 (1982) 97.

    Article  CAS  Google Scholar 

  19. Hurley, L. S., and Bell, L. T., Proc. Soc. expl Biol. Med.149 (1975) 830.

    Article  CAS  Google Scholar 

  20. Prasad, A. S., Vreewer, G. J., Schoomaker, E. B., and Rabbani, P., J. Am. med. Assoc.240 (1978) 2166.

    Article  CAS  Google Scholar 

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Mulhern, S.A., Stroube, W.B. & Jacobs, R.M. Alopecia induced in young mice by exposure to excess dietary zinc. Experientia 42, 551–553 (1986). https://doi.org/10.1007/BF01946698

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