Summary
Second generation mice were exposed to normal (50 ppm, Group I) or excess (2000 ppm, Group II) zinc in the maternal diet during gestation and lactation, then weaned and continued on the mother's diet until sacrifice at 8 weeks. Tibia zinc reflected dietary intake. Group II had reduced plasma copper, body weight, and hematocrit; the second coat of hair appeared late and was lighter in color than Group I, possibly as an effect of copper and pigmentation development and hair growth.
References
Porter, K. G., McMaster, D., Elmes, m. E., and Love, A. H. G., LancetII (1977) 2774.
Hoogenraad T. U., Van Den Hamer, C. J. A., Koevoet, R., and Korver, E. G. M., LancetII (1978) 1262.
Bremmer, B. I., Young, B. W., and Mills, C. F., Br. J. Nutr.36 (1976) 551.
Smith, W. H., Plumlee, M. P., and Beeson, W. M., Science128 (1958) 1280.
National Research Council, Nutrient Requirments of Laboratory Animals, pp. 38–53. National Academy of Sciences, Washington, DC. 1978.
Stroube, W. B., Cunningham, W. C., Tanner, J. T., Bradley, B. D., and Gaylor, G., J. Radioanalyt. Chem.69 (1982) 453.
Marston, H. R., Physiol. Rev.32 (1952) 66.
Menkes, J. H., Alter, M., Steigleder, G. K., Weakley, D. R., and Sung, J. H., Pediatrics29 (1962) 764.
Obeck, D. K., Lab. Anim., Sci.28 (1978) 698.
Bleavins, M. R., Aulerich, R. J., Hochstein, J. R., Hornshaw, T. C., and Napolitano, A. C., N. Nutr.113 (1983) 2360.
Underwood, E. J., Trace Elements in Human and Animal Nutrition, 4th edn, p. 80. Academic Press, New York 1977.
Evans, G. W., Grace, C. I., and Votava, H. J., Am. J. Physiol.228 (1975) 501.
Reeves, J. R. T., and Maibach, H. I., in: Advances in Modern Toxicology, vol. 4, p. 487. Eds F. N. Marzulli and H. I. Maibach. Hemisphere, Washington, DC 1977.
Pierard, G. E., J. cutan Path.6 (1979) 237.
Metter, D., and Vock, R., Z. Rechtsmed.91 (1984) P201.
Clercq, E. D., Descamps, J., Somer, P. D., Samyn, C., and Smets, G., Experientia36 (1980) 1197.
Lee, K. P., Terrill, J. B., and Henry, N. W., J. Toxic. envir. Hlth3 (1977) 859.
Chanda, J. J., Anderson, H. A., Glamb, R. W., Lomatch, D. L., Wolff, M. S., Voorhees, J. J., and Selikoff, I. J., Envir. Res.29 (1982) 97.
Hurley, L. S., and Bell, L. T., Proc. Soc. expl Biol. Med.149 (1975) 830.
Prasad, A. S., Vreewer, G. J., Schoomaker, E. B., and Rabbani, P., J. Am. med. Assoc.240 (1978) 2166.
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Mulhern, S.A., Stroube, W.B. & Jacobs, R.M. Alopecia induced in young mice by exposure to excess dietary zinc. Experientia 42, 551–553 (1986). https://doi.org/10.1007/BF01946698
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DOI: https://doi.org/10.1007/BF01946698