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Release of calcitonin gene-related peptide from a human medullary carcinoma of the thyroid in vitro

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Summary

The secretion of human calcitonin gene-related peptide was examined in perifusates of medullary carcinoma of the thyroid with a sensitive radioreceptor assay. Calcitonin gene-related peptide was released after the addition of calcium (25–100 mM), in a dose-dependent manner. The results indicate that human medullary carcinomas of the thyroid secrete the calcitonin gene-related peptide as well as calcitonin.

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References

  1. Amara, S.G., Jonas, V., Rosenfeld, M. G., Ong, E. S., and Evans, R. M>, Nature298 (1982) 240.

    Article  CAS  PubMed  Google Scholar 

  2. Rosenfeld, M.G., Mermod, J.J., Amara, S.G., Swanson, L.W., Sawchenko, P.E., Rivier, J., Vale, W.W., and Evans, R.M., Nature304 (1983) 129.

    Article  CAS  PubMed  Google Scholar 

  3. Morris, H.R., Panico, M., Etienne, T., Tippins, J., Girgis, S.I., and MacIntyre, I., Nature308 (1984) 746.

    Article  CAS  PubMed  Google Scholar 

  4. Tschopp, F.A., Henke, H., Petermann, J.B., Tobler, P.H., Janzer, R., Hökfelt, T., Lundberg, J.M., Cuello, C., and Fischer, J.A., Proc. natn. Acad. Sci. USA82 (1985) 248.

    Article  CAS  Google Scholar 

  5. Conlon, J.M., McCulloch, A.J., and Alberti, K.G.M.M., Diabetes32 (1983) 723.

    Article  CAS  PubMed  Google Scholar 

  6. Girgis, S.I., MacDonald, D.W.R., Steveson, J.C., Bevis, P.J.R., Lynch, C., Wimalawansa, S.J., Self, C.H., Morris, H.R., and MacIntyre, I., Lancet2 (1985) 14.

    Article  CAS  PubMed  Google Scholar 

  7. Amara, S., Arriza, J.L., Leff, S.E., Swanson, L.W., Evans, R.M., and Rosenfeld, M.G., Science229 (1985) 1094.

    Article  CAS  PubMed  Google Scholar 

  8. Brain, S.D., Williams, T.J., Tippins, J.R., Morris, H.R., and MacIntyre, I., Nature313 (1985) 54.

    Article  CAS  PubMed  Google Scholar 

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Ohashi, M., Fujio, N. & Ibayashi, H. Release of calcitonin gene-related peptide from a human medullary carcinoma of the thyroid in vitro. Experientia 42, 829–830 (1986). https://doi.org/10.1007/BF01941541

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  • DOI: https://doi.org/10.1007/BF01941541

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