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Aplysianin-A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare,Aplysia kurodai

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Summary

Aplysianin-A, an antibacterial and antineoplastic factor in the albumen gland of the sea hareAplysia kurodai, was isolated. It had a molecular weight of approximately 320 kD and consisted of subunits with a molecular weight of 85 kD. It contained 9.8% neutral sugar. Aplysianin A showed 50% inhibition ofBacillus subtilis growth at a concentration of 4 μg protein/ml and 50% lysis of murine MM46 tumor cells at 14 ng protein/ml. A partial identity of antigenic specificity of the purified specimen with an antineoplastic factor fromAplysia eggs was observed in immunodiffusion tests.

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Authors and Affiliations

  1. School of Fischeries Sciences, Kitasato University, Sanrikucho, 022-01, Iwate, Japan

    H. Kamiya & K. Muramoto

  2. Faculty of Pharmaceutical Sciences, Teikyo University, Sagamikocho, 199-01, Kanagawa, Japan

    M. Yamazaki

Authors
  1. H. Kamiya
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  2. K. Muramoto
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  3. M. Yamazaki
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Additional information

Acknowledgment. We are indebted to the staff of Fisheries Research Laboratory, Faculty of Agriculture, University of Tokyo, Maisaka, for the collection of sea hares.

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Kamiya, H., Muramoto, K. & Yamazaki, M. Aplysianin-A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare,Aplysia kurodai. Experientia 42, 1065–1067 (1986). https://doi.org/10.1007/BF01940736

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  • DOI: https://doi.org/10.1007/BF01940736

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