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(+)-curcuphenol and dehydrocurcuphenol, novel sesquiterpenes which inhibit H,K-ATPase, from a marine spongeEpipolasis sp

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Summary

Two H, K-ATPase inhibitors and an inactive related compound have been isolated from a marine spongeEpipolasis sp. They are aromatic sesquiterpene α-curcumenes

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Authors and Affiliations

  1. Laboratory of Marine Biochemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

    N. Fusetani, M. Sugano, S. Matsunaga & K. Hashimoto

Authors
  1. N. Fusetani
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  2. M. Sugano
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  3. S. Matsunaga
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  4. K. Hashimoto
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Additional information

Acknowledgment. Thanks are due to Professor Paul J. Scheuer, University of Hawaii, for reading this manuscript. We are indebted to Professor P. R. Bergquist, University of Auckland, for identification of the sponge. We thank Mr M. Shimizu of the Central Research Laboratories of Yamanouchi Pharmaceutical Co. Ltd. for HREIMS measurements. We are also indebted to Dr H. Shikama and Ms. A. Ohta of the same laboratories for bioassays.

This sponge is very similar toE. novaelandiae except for its gross morphology.

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Fusetani, N., Sugano, M., Matsunaga, S. et al. (+)-curcuphenol and dehydrocurcuphenol, novel sesquiterpenes which inhibit H,K-ATPase, from a marine spongeEpipolasis sp. Experientia 43, 1234–1235 (1987). https://doi.org/10.1007/BF01945540

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  • DOI: https://doi.org/10.1007/BF01945540

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