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Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline

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Summary

The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).

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Authors and Affiliations

  1. Preclinical Research, Pharma, Sandoz Ltd., CH-4002, Basel, Switzerland

    E. Flückiger, U. Briner, B. Clark, A. Closse, A. Enz, P. Gull, A. Hofmann, R. Markstein, L. Tolcsvai & H. R. Wagner

Authors
  1. E. Flückiger
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  2. U. Briner
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  3. B. Clark
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  4. A. Closse
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  5. A. Enz
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  6. P. Gull
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  7. A. Hofmann
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  8. R. Markstein
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  9. L. Tolcsvai
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  10. H. R. Wagner
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Additional information

In memory of Dr Annemarie Closse, who died 14 June 1987.

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Flückiger, E., Briner, U., Clark, B. et al. Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline. Experientia 44, 431–436 (1988). https://doi.org/10.1007/BF01940539

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  • DOI: https://doi.org/10.1007/BF01940539

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