Summary
The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
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Literature
Flückiger, E., and Wagner, H. R., Experientia24 (1968) 1130.
Flückiger, E., Briner, U., Doepfner, W., Kovacs, E., Marbach, P., and Wagner, H. R., Experientia34 (1978) 1330.
Flückiger, E., Briner, U., Bürki, H. R., Marbach, P., Wagner, H. R., and Doepfner, W., Experientia35 (1979) 1677.
Gull, P., Deutsche Offenlegungsschrift DE 3′127′845 Al.
Fuller, R. W., Clemens, J. A., Kornfeld, E. C., Snoddy, H. D., Smalstig, E. B., and Bach, N. J., Life Sciences24 (1979) 375.
Grosvenor, C. E., and Turner, C. W., Proc. Soc. exp. Biol. Med.94 (1957) 816.
Irwin, S., in: Animal and Clinical Pharmacological Techniques in Drug Evaluation, p. 36. Eds H. Nodine and P. E. Siegler. Year Book Med. Publ., Philadelphia 1964.
Ungerstedt, U., and Arbuthnot, G. W., Brain Res.24 (1970) 845.
Johnson, A. M., Löw, D. M., and Vigouret, J. M., Br. J. Pharmac.56 (1976) 59.
Glowinski, J., and Iversen, L. L., J. Neurochem.13 (1966) 655.
Karoum, F., Gillin, J. C., and Wyatt, R. J., J. Neurochem.25 (1975) 653.
Koslow, S. H., Cattabeni, F., and Costa, E., Science176 (1972) 177.
Cattabeni, F., Koslow, S. H., and Costa, E., Science178 (1972) 166.
Novicky, M., and Rogh, R. H., Prog. Neuro-Psychopharmac.2 (1978) 139.
Closse, A., Frick, W., Markstein, R., Maurer, R., and Nordmann, R., J. neural Transm.62 (1985) 231.
Markstein, R., Enz, A., Vigouret, J. M., Jaton, A., Closse, A., Briner, U., and Gull, P., J. neural Transm.69 (1987) 179.
Clark, B. J., J. Pharmac. (Paris)10 (4 bis) (1979) 439.
Venetikou, M. S., Burrin, J. M., Woods, C. A., Yeo, T. H., Brownell, J., and Adams, E. F., Acta endocr. (Kbh)116 (1987) 287.
Flückiger, E., Briner, U., Doepfner, W., Kovacs, E., Marbach, P., and Wagner, H. R., Experientia34 (1978) 1330.
Flückiger, E., in: Dopamine and Neuroendocrine Active Substances, p. 1. Eds E. del Pozo and E. Flückiger. Academic Press, London 1983.
Revel, J., Brownell, J., Steiner, J. L., Gaillard, R. C., and Rosenthaler, J., Br. J. clin. Pharmac.22 (1986) 1.
Van der Hejiden, P. F. M., Rolland, R., and Brownell, J., Gynec. Endocr.1 (1987) 93.
Rubin, A., Lemberger, L., and Dhahir, P., Clin. pharmac. Ther.30 (1981) 258.
Flückiger, E., J. neural Transm.18 Suppl. (1983) 189.
Flückiger, E., in: Physiology of Mammary Glands, p. 71. Eds A. Yokoyama, H. Mizuno and H. Nagasawa. Japan Sci. Soc. Press, Tokyo 1978.
Fuchs, A. R., Cubile, L., Dawood, M. Y., and Jørgensen, F. S., Endocrinology114 (1984) 462.
Crowley, W. R., Shyr, S. W., Kacsoh, B., and Grosvenor, C. E., Endocrinology121 (1987) 14.
Grosvenor, C. E., Proc. soc. exp. Biol. Med.91 (1952) 294.
Flückiger, E., and Vigouret, J. M., Post-grad. med. J.57, Suppl. 1 (1981) 55.
DaPrada, M., Bonetti, E. P., and Keller, H. H., Neurosci. Lett.6 (1977) 349.
Keller, H. H., Bonetti, E. P., Pieri, L., and DaPrada, M., in: Lisuride and Other Dopamine Agonists, p. 79. Eds D. B. Clane, R. Horowski, R. J. McDonald and W. Wuttke. Raven Press, New York 1983.
Bonetti, E. P., DaPrada, M., and Angioi, R. M., Experientia37 (1981) 666.
Römer, D., Büscher, H. H., Hill, R. C., Pless, J., Bauer, W., Cardinaux, F., Closse, A., Hauser, D., and Huguenin, R., Nature268 (1977) 547.
Gabrowska, M., Antkiewicz, L., Maj, J., and Michaluk, J., Pol. J. Pharmac. Pharm.25 (1973) 29.
Clark, B. J., Post-grad, med. J.57, Suppl. 1 (1981) 45.
Clark, B. J., and Menninger, K., Circ. Res.46 Suppl. 1 (1980) 59.
Clark, B. J., Scholtysik, G., and Flückiger, E., Acta endocr.18, Suppl. 216 (1978) 75.
G. Scholtysik, Br. J. Pharmac.62 (1978) 379.
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In memory of Dr Annemarie Closse, who died 14 June 1987.
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Flückiger, E., Briner, U., Clark, B. et al. Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline. Experientia 44, 431–436 (1988). https://doi.org/10.1007/BF01940539
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DOI: https://doi.org/10.1007/BF01940539