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The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat

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Summary

The level of somatostatin in the hypothalamus was higher in satiated rats than in hungry rats. Elevating hypothalamic somatostatin levels by administering somatostatin into the hypothalamus produced a decrease in food intake, whereas lowering hypothalamic somatostatin levels by administering cysteamine into the peritoneal cavity produced an increase in food intake in rats.

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Authors and Affiliations

  1. Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan

    L. T. Ho

  2. Department of Physiology, China Medical College, Taichung, Taiwan

    Y. F. Chern

  3. Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan

    M. T. Lin

Authors
  1. L. T. Ho
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  2. Y. F. Chern
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  3. M. T. Lin
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Additional information

This work was supported by grants from the National Science Council (Taipei, Taiwan, Republic of China).

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Ho, L.T., Chern, Y.F. & Lin, M.T. The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat. Experientia 45, 161–162 (1989). https://doi.org/10.1007/BF01954859

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  • DOI: https://doi.org/10.1007/BF01954859

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