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Altered brain cholinergic enzymes activity in the genetically obese rat

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Summary

Genetically obese male Zucker rats (fa/fa) and their lean littermates (Fa/-) were used in this experiment. Fourteen-week-old obese and lean littermates were sacrificed and choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) enzymes were assayed in specific brain regions. The assays of these enzymes indicate that obese animals and a significantly lower ChAT activity in the cerebellum, pons, and cerebral cortex and a significant increase in ChAT activity in the thalamus and hypothalamus. Meanwhile, the cerebral cortex, cerebellum, midbrain, thalamus and hypothalamus of the obese animals showed significantly higher AChE activity than their lean littermates. It was concluded from this study that obesity may be associated with changes in the enzymes of the brain cholinergic system.

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Authors and Affiliations

  1. College of Pharmacy, Florida A&M University, 32307, Tallahassee, Florida, USA

    C. B. Goodman & K. F. A. Soliman

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  1. C. B. Goodman
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  2. K. F. A. Soliman
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Additional information

This work was supported by a grant from the National Aeronautics and Space Administration (NAG 2-411), a grant from the National Institutes of Health (NIH RR 0811), and a grant from the Division of Research Resources, National Institutes of Health (NIH Grant RR 03020).

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Goodman, C.B., Soliman, K.F.A. Altered brain cholinergic enzymes activity in the genetically obese rat. Experientia 47, 833–835 (1991). https://doi.org/10.1007/BF01922466

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  • DOI: https://doi.org/10.1007/BF01922466

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