Abstract
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition-without the need for reinfusion of the shed blood-starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
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Guarini, S., Bazzani, C., Tagliavini, S. et al. Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP). Experientia 48, 663–667 (1992). https://doi.org/10.1007/BF02118314
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DOI: https://doi.org/10.1007/BF02118314