Abstract
Molecular genetic analyses of osteochondrodysplasias in mice and humans have recently led to the identification of mutations in genes encoding structural proteins growth factor receptors and sulphate transporters. Further analyses of such inherited disorders, using rapid techniques for gene mapping, positional cloning and mutation detection, will undoubtedly uncover other genes that are important for skeletal development. Together with studies of transgenic mice, in which specific genes that are expressed in the skeleton are mutated, these analyses will provide insight into genes that are essential for skeletal morphogenesis.
Similar content being viewed by others
References
Warman, M. L., Abbott, M., Apte, S. S., Hefferon, T., McIntosh, I., Cohn, D., Hecht, J., Olsen, B. R., and Francomano, C.A., Nature Genet.5 (1993) 79.
Shiang, R., Thompson, L. M., Zhu, Y.-Z., Church, D. M., Fiedler, T. J., Bocian, M., Winokur, S. T., and Wasmuth, J. J., Cell78 (1994) 335.
Reardon, W., Winter, R. M., Rutland, P., Pulleyn, L. J., Jones, B. M., and Malcolm, S., Nature Genet.8 (1994) 98.
Hastbacka, J., de la Chapelle, A., Mahtani, M. M., Clines, G., Reeve-Daly, M. P., Daly, M., Hamilton, B. A., Kusumi, K., Trivedi, B., Weaver, A., Coloma, A., Lovett, M., Buckler, A., Kaitila, I., and Lander, E. S., Cell78 (1994) 1073.
Li, Y., Lacerda, D. A., Warman, M. L., Beier, D. R., Yoshioka, H., Ninomiya, Y., Oxford, J. T., Morris, N. P., Andrikopoulos, K., Ramirez, F., Wardell, B. B., Lifferth, G. D., Teuscher, C., Woodward, S. R., Taylor, B. A., Seegmiller, R. E., Olsen, B. R., Cell February 1995.
Seegmiller, R. E., Fraser, F. C., and Sheldon, H., J. Cell Biol.48 (1971) 580.
Seegmiller, R. E., Ferguson, C. C., and Sheldon, H., J. Ultrastr. Res.38 (1972) 288.
Monson, C. B., and Seegmiller, R. E., J. Bone Jt Surg.63A (1981) 637.
Brunner, H. G., van Beersum, S. E. C., Warman, M. L., Olsen, B. R., Ropers, H.-H., and Mariman, E. C. M., Hum. molec. Genet.3 (1994) 1561.
Vikkula, M., Mariman, E. C. M., Lui, V. C. H., Zhidkova, N. I., Tiller, G. E., Goldring, M. B., van Beersum, S. E. C., Malefijt, M., van den Hoogen, F. H. J., Ropers, H.-H., Mayne, R., Cheah, K. S. E., Olsen, B. R., Warman, M. L., and Brunner, H. G., Cell February 1995.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Olsen, B.R. The roles of collagen genes in skeletal development and morphogenesis. Experientia 51, 194–195 (1995). https://doi.org/10.1007/BF01931087
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01931087