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Immunohistochemical evidence that tumors elicit the synthesis of estrogen receptors in the submandibular gland of female rats

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Abstract

We have demonstrated the presence of estrogen receptor mRNA and the mature protein in the cytoplasm and nucleus, respectively, of a 9,10-dimethyl-1,2-benzathracene-induced submandibular gland tumor in female rats. We have previously shown that progesterone receptors are also present in human salivary gland tumors. These results suggest that endocrine therapy may be effective in treatment of submandibular gland tumors.

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References

  1. King, W. J., and Greene, G. L., Nature307 (1984) 745.

    Article  CAS  PubMed  Google Scholar 

  2. Liposits, Z., Kallo, I., Coen, C. W., Paull, W. K., and Flerko, B., Histochemistry93 (1990) 233.

    Article  CAS  PubMed  Google Scholar 

  3. McClellan, M. C., West, N. B., Tacha, D. E., Greene, G. L., and Brenner, R. M., Endocrinology114 (1984) 2002.

    Article  CAS  PubMed  Google Scholar 

  4. Okulicz, W. C., Padykula, H. A., Kaiserman-Abramof, I. R., and Longcope, C., J. Cell Biol.105 (1987) 9A.

    Article  Google Scholar 

  5. Okulicz, W. C., Savasta, A. M., Hoberg, L. M., and Longcope, C., Endocrinology125 (1989) 930.

    Article  CAS  PubMed  Google Scholar 

  6. Horwitz, K. B., McGuire, W. L., Pearson, O. H., and Segaloff, A., Science189 (1975) 726.

    Article  CAS  PubMed  Google Scholar 

  7. Paridaens, R., Sylvester, R. J., Ferrazzi, E., Legros, N., Leclercq, G., and Heuson, J. C., Cancer46 (1980) 2889.

    Article  CAS  PubMed  Google Scholar 

  8. Ozono, S., Onozuka, M., Sato, K., and Ito, Y., Cell Struct. Func.16 (1991) 511.

    Article  CAS  Google Scholar 

  9. Ozono, S., Onozuka, M., Sato, K., and Ito, Y., Cell Struct. Func.17 (1992) 169.

    Article  CAS  Google Scholar 

  10. Koike, S., Sakai, M., and Muramatsu, M., Nucleic Acids Res.15 (1987) 2499.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Lauber, A. H., Mobbs, C. V., Muramatsu, M., and Pfaff, D. W., Endocrinology129 (1990) 3180.

    Article  Google Scholar 

  12. Bakker, G. H., Setyono-Han, H., Portengen, S. H., Jong, F. H. D., Foekens, J. A., and Klijin, J. G. M., Endocrinology125 (1989) 1593.

    Article  CAS  PubMed  Google Scholar 

  13. McGuire, W. L., Carbone, P. P., Sears, M. L., and Escher, G. C., Estrogen Receptors in Human Breast Cancer: An Overview, p. 7. Eds W. L. McGuire, P. P. Carbone and E. P. Voumer. Raven Press, New York 1975.

    Google Scholar 

  14. Shyamala, G., and Ferenczy, A., Endocrinology115 (1984) 1078.

    Article  CAS  PubMed  Google Scholar 

  15. Stumpf, W. E., and Sar, M., Autoradiographic Localization of Estrogen, Androgen, Progestin, and Glucocorticosteroid in ‘Target Tissues’ and ‘Non-target Tissues’, p. 41. Ed. J. R. Pasqualini. Marcel Dekker, New York 1976.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Kanagawa Dental College, 82 Inaoka-cho, 238, Yokosuka, Japan

    S. Ozono, K. Sato, Y. Ito & N. Kubota

  2. Department of Histology, Kanagawa Dental College, 82 Inaoka-cho, 238, Yokosuka, Japan

    H. Hayashi & H. Kato

  3. Department of Physiology, Tokyo Dental College, 2-2 Masago 1 Chome, 261, Chiba, Japan

    T. Yamamoto

  4. Department of Physiology, Gifu University, School of Medicine, 40 Tsukasa-machi, 500, Gifu, Japan

    S. Ozono & K. Watanabe

  5. Department of Anatomy, Gifu University, School of Medicine, 40 Tsukasa-machi, 500, Gifu, Japan

    M. Onozuka

Authors
  1. S. Ozono
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  2. K. Sato
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  3. Y. Ito
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  4. N. Kubota
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  5. H. Hayashi
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  6. H. Kato
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  7. T. Yamamoto
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  8. K. Watanabe
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  9. M. Onozuka
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Ozono, S., Sato, K., Ito, Y. et al. Immunohistochemical evidence that tumors elicit the synthesis of estrogen receptors in the submandibular gland of female rats. Experientia 51, 220–222 (1995). https://doi.org/10.1007/BF01931100

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  • DOI: https://doi.org/10.1007/BF01931100

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