Abstract
5-(Hydroxybenzyl)uracils are obtained by condensation of 5-hydroxymethyluracil (I) with phenols in the presence of CF3COOH [1]. However, the activity of CF3COOH is insufficient for aromatic compounds that do not contain electron-donor substituents. Thus, according to PMR data, the reaction between equivalent amounts of I and C6H6 in CF3COOH is complete only after 3 days. However, benzene derivatives containing electron-acceptor substituents are practically unreactive. Anhydrous HP, in which even benzotrifluoride reacts, is a considerably more efficient agent.
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Literature cited
R. Brossmer, Angew. Chem., Int. Ed. in English, 6, 702 (1967).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1433–1434, October, 1974.
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German, L.S., Polishchuk, V.R. & Bekker, G.Y. 5-Benzyluracil and its derivatives. Chem Heterocycl Compd 10, 1262 (1974). https://doi.org/10.1007/BF00470180
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DOI: https://doi.org/10.1007/BF00470180