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Syntheses and reactions of pyrimidine derivatives

XVIII. A study of the activity of the methyl groups in 2-methylpyrimidine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

An increase in the electron-donating capacity of a substitution in position 4 of the pyrimidine ring (OH < SH < NH2) leads to a decrease in the reactivity of a methyl group in position 2. The methyl group in 2-methylpyrimidine is less active than that in 4-methylpyrimidine. The hypothesis has been put forward that the lowering of the reactivity of 2-methylpyrimidine is due to the symmetry of its structure.

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Authors and Affiliations

  1. Institute of Experimental Medicine AMS USSR, Leningrad

    V. A. Serzhanina, N. V. Khromov-Borisov & R. S. Karlinskaya

Authors
  1. V. A. Serzhanina
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  2. N. V. Khromov-Borisov
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  3. R. S. Karlinskaya
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Additional information

For part XVI, see [1].

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Serzhanina, V.A., Khromov-Borisov, N.V. & Karlinskaya, R.S. Syntheses and reactions of pyrimidine derivatives. Chem Heterocycl Compd 4, 388–389 (1968). https://doi.org/10.1007/BF00755293

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  • DOI: https://doi.org/10.1007/BF00755293

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