Abstract
Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melano-statin are active to a lesser degree. The selective effect on primary learning (ACTH4–7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor)-all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 68, No. 10, pp. 1322–1329, October, 1982.
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Medvedev, V.I., Bakharev, V.D. & Kaurov, O.A. Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats. Neurosci Behav Physiol 15, 240–246 (1985). https://doi.org/10.1007/BF01182994
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DOI: https://doi.org/10.1007/BF01182994